Science in sports Pure Glutamine 2011



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Brand: Science in sports
Category: Sports Nutrition

Description: Glutamine is important for optimal muscle growth and adaptation. 250g Glutamine supplement. | | Although glutamine is classified by nutritionists as a 'non-essential amino acid', it is probable that no single amino acid has received as much attention in clinical nutrition research and increasingly this interest has spread to sports nutrition. | | In order to understand how a "non-essential amino acid" can attract so much attention it is necessary to understand where the term "non-essential" comes from. An amino acid is only considered essential if it is not possible for the body to make the particular amino acid when there is adequate supply of other 'essential' amino acids. Since it is possible to make glutamine from many different amino acids, including glutamic acid, valine and isoleucine, it is not considered essential. However, the fact that the body has a number of ways to produce glutamine may serve to illustrate its importance. | | Glutamine is also a precursor for many other amino acids, an important fuel for the immune system, the brain and gut mucosal cells and is at the heart of a mechanism controlling acid/base balance. It may also be a direct regulator of protein synthesis and regulation. Thus glutamine is at the heart of a metabolic cross roads and its adequate supply is thus crucial for optimal functioning of the body. | | Glutamine has been used routinely in hospitals for the treatment of burns and other trauma patients where it has been shown to help improve immune function. Recently research has focused on the parallels between the trauma of 'hospitalisation' and the trauma of exercise stress. Under these conditions the body's requirement for glutamine may exceed its capacity to produce it, and in these conditions glutamine may become 'conditionally essential'. | | Glutamine is the largest store of amino acid in the body, with large amounts being stored in the muscle. Glutamine accounts for over 60% of the total intra-muscular amino acid pool. However, release rates are so high that even in resting muscle it is likely that all these stores would be used up within 7 hours if de-novo synthesis did not take place. During exercise release rates from muscle increase dramatically, leaving both muscle and plasma levels depleted for between hours and days depending on the duration and intensity of the exercise. Glutamine levels have been shown to be low in athletes with over training syndrome, and much recent research has focused on its role in the prevention of this syndrome. | | Athletes in hard training are often prone to infections, particularly infections of the throat and the upper respiratory tract. There is mounting evidence that hard training can reduce immune function. Researchers have noted the parallels between the stress of hard training and the stress suffered by hospitalised trauma patients, particularly those suffering from burns. As mentioned above, these patients are routinely given glutamine supplementation to protect glutamine status and this has been shown to improve immune function %u2013 similar benefits in athletic populations have been reported. | | Glutamine is important for optimal muscle growth and adaptation. Animal studies suggest that glutamine stimulates protein synthesis and inhibits protein breakdown in muscles. In healthy subjects, infusing sufficient glutamine to double plasma glutamine concentrations has no effect on whole body proteolysis (protein breakdown), but slightly increases whole body synthesis. This may be due to the effect of glutamine on cell volume. Glutamine is taken up by the muscle cell thereby increasing the volume of the cell by drawing fluid into the cell due to the increase in intracellular osmolality. This may then promote muscle hypertrophy through the stimulation of nitric-oxide synthase in a similar way that a mechanical stretch influences gene expression (Tidball et al 1999). Ensuring adequate muscle glycogen stores post exercise is another crucial factor in recovery and adaptation to exercise, and glutamine has been shown to stimulate muscle glycogen synthesis from glucose. Therefore ensuring adequate glutamine levels is essential in order to ensure optimal muscle function, muscle growth and resistance to infection. | | Taking a protein supplement rich in glutamine in addition to carbohydrate, post exercise, may be sufficient to maintain glutamine status (Van Hall et al, 2000) %u2013 our Rego is very good for this. However, most post exercise protein carbohydrate products have a significant amount of calories, ideal in periods of hard training when it is crucial to maintain muscle glycogen stores, but there are times when it is useful to take glutamine in a less calorific form. This may include times after shorter intense workouts, during taper for competition and stressful situations not necessarily caused by training %u2013 e.g. injury and infection. Glutamine is readily soluble in water and has a pleasant taste, so the easiest way to consume it is to dissolve a few grams of pure L-glutamine into water or your favourite cordial. Many athletes have found it beneficial to use a 2-5g dose immediately after workouts and 2 hours post workout, with additional doses on an empty stomach either last thing at night or first thing in the morning in periods of heavy stress. | | Glutamine ingredients: | L-glutamine.


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